6DKB
Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10b.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | High affinity nerve growth factor receptor | polymer | 320 | 36110.5 | 1 | UniProt (P04629) Pfam (PF07714) | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | B (A) | 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide | non-polymer | 521.5 | 1 | Chemie (FKY) | |||
| 3 | C (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 479 - 796 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| Gly 477 | - | expression tag |
| Ser 478 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36110.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 521.5 | |
| All* | Total formula weight | 36632.0 |
