6DGR

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10638

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor gamma	polymer	297	34152.4	2	UniProt (P37231) Pfam (PF00104)	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	C (A)	(5Z)-5-({4-[2-(thiophen-2-yl)ethoxy]phenyl}methylidene)-1,3-thiazolidine-2,4-dione	non-polymer		331.4	1	Chemie (GDY)
3	D, E (A, B)	water	water		18.0	226	Chemie (HOH)

Sequence modifications

A, B: 203 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 181	-	initiating methionine
Ala 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
Val 189	-	expression tag
Asp 190	-	expression tag
Asp 191	-	expression tag
Asp 192	-	expression tag
Asp 193	-	expression tag
Lys 194	-	expression tag
Met 195	-	expression tag
Glu 196	-	expression tag
Asn 197	-	expression tag
Leu 198	-	expression tag
Tyr 199	-	expression tag
Phe 200	-	expression tag
Gln 201	-	expression tag
Gly 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68304.8
Non-Polymers*	Number of molecules	1
	Total formula weight	331.4
All*	Total formula weight	68636.2

*Water molecules are not included.