6DFH
BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (A, C, D) | Envelope glycoprotein gp160 | polymer | 476 | 53497.8 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, F, J (B, E, F) | Envelope glycoprotein gp160 | polymer | 162 | 18209.6 | 3 | UniProt (Q2N0S5) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | C, G, K (H, G, I) | germline-reverted BG18 fragment antigen binding heavy chain | polymer | 233 | 24602.6 | 3 | Homo sapiens | ||
| 4 | D, H, L (L, J, K) | germline-reverted BG18 fragment antigen binding light chain | polymer | 214 | 22861.2 | 3 | Homo sapiens | ||
| 5 | BA, CA, DA, EA, FA... (b, c, d, e, f...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 18 | In PDB GlyTouCan (G42666HT) | |||
| 6 | HA, R, Z (h, R, Z) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G42227JK) | |||
| 7 | AA, IA, S (a, i, S) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 3 | In PDB GlyTouCan (G46836GH) | |||
| 8 | AB, BB, KA, LA, MA... (D, F, A, B, C...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
A, C, D: 31 - 508 (UniProt: Q2N0S6)
B, E, F: 512 - 664 (UniProt: Q2N0S5)
| PDB | External Database | Details |
|---|---|---|
| Glu 73 | Ala 72 | conflict |
| Glu 110 | Ser 109 | conflict |
| Tyr 134 | Val 133 | conflict |
| Ala 135 | Thr 134 | conflict |
| Pro 136 | Asn 135 | conflict |
| Lys 137 | Asn 136 | conflict |
| Leu 138 | Ile 137 | conflict |
| Arg 139 | Thr 138 | conflict |
| Ser 140 | Asp 139 | conflict |
| Met 141 | Asp 140 | conflict |
| Ile 154 | Leu 145 | conflict |
| Ile 271 | Met 270 | conflict |
| Leu 288 | Phe 287 | conflict |
| Val 304 | Arg 303 | conflict |
| Tyr 319 | Ala 316 | conflict |
| Phe 320 | Thr 317 | conflict |
| Val 323 | Ile 320 | conflict |
| Leu 323 | Ile 321 | conflict |
| Val 326 | Ile 324 | conflict |
| Met 328 | Gln 326 | conflict |
| Asn 332 | Thr 330 | conflict |
| Ile 333 | Val 331 | conflict |
| Gln 363 | Asn 361 | conflict |
| Leu 414 | Ile 411 | conflict |
| Ile 415 | Thr 412 | conflict |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 519 | Phe 516 | conflict |
| Pro 559 | Ile 556 | conflict |
| Pro 561 | Ala 558 | conflict |
| His 585 | Arg 582 | conflict |
| Cys 605 | Thr 602 | conflict |
| Gly 665 | - | expression tag |
| Thr 666 | - | expression tag |
| Lys 667 | - | expression tag |
| His 668 | - | expression tag |
| His 669 | - | expression tag |
| His 670 | - | expression tag |
| His 671 | - | expression tag |
| His 672 | - | expression tag |
| His 673 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 357513.8 | |
| Branched | Number of molecules | 24 |
| Total formula weight | 14077.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 375572.5 |
