6DEB
Crystal Structure of Bifunctional Enzyme FolD-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase in the Complex with Methotrexate from Campylobacter jejuni
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional protein FolD | polymer | 285 | 30656.7 | 2 | UniProt (Q0PA35) Pfam (PF00763) Pfam (PF02882) | Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) | |
| 2 | C (A) | GUANINE | non-polymer | 151.1 | 1 | Chemie (GUN) | |||
| 3 | D (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | E, G, H, M, P (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | F, L, O (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | I (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 7 | J, K (B) | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
| 8 | N (B) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 9 | Q, R (A, B) | water | water | 18.0 | 497 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 282 (UniProt: Q0PA35)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61313.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1942.3 | |
| All* | Total formula weight | 63255.8 |
