6DE4
Homo sapiens dihydrofolate reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 186 | 21349.5 | 2 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (Human) | |
| 2 | C, J (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, K (A, B) | 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid | non-polymer | 416.5 | 2 | Chemie (G6Y) | |||
| 4 | E, N (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F, G (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | H, I, Q, R (A, B) | ETHANOL | non-polymer | 46.1 | 4 | Chemie (EOH) | |||
| 7 | L, M (B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | O, P (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 9 | S, T (A, B) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42699.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3035.4 | |
| All* | Total formula weight | 45734.5 |
