6DCX

iASPP-PP-1c structure and targeting of p53

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	339	38473.9	2	UniProt (P62136) Pfam (PF16891) Pfam (PF00149)	Homo sapiens (Human)	PP-1A
2	C, D (C, D)	RelA-associated inhibitor	polymer	228	24939.8	2	UniProt (Q8WUF5) Pfam (PF12796) Pfam (PF14604)	Homo sapiens (Human)	Inhibitor of ASPP protein,Protein iASPP,NFkB-interacting protein 1,PPP1R13B-like protein

Sequence modifications

A, B: 1 - 330 (UniProt: P62136)

PDB	External Database	Details
Gly -8	-	expression tag
Pro -7	-	expression tag
Gly -6	-	expression tag
Tyr -5	-	expression tag
Gln -4	-	expression tag
Asp -3	-	expression tag
Pro -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag

C, D: 608 - 828 (UniProt: Q8WUF5)

PDB	External Database	Details
Gly 601	-	expression tag
Pro 602	-	expression tag
Gly 603	-	expression tag
Tyr 604	-	expression tag
Gln 605	-	expression tag
Asp 606	-	expression tag
Pro 607	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	126827.6
All*	Total formula weight	126827.6

*Water molecules are not included.