6DCO

Bcl-xL complex with Beclin 1 BH3 domain T108D

Replaces:  5VB4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bcl-2-like protein 1,Bcl-2-like protein 1	polymer	156	17703.7	2	UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (Human)	Bcl2-L-1,Apoptosis regulator Bcl-X,Bcl2-L-1,Apoptosis regulator Bcl-X
2	C, D (C, D)	Beclin-1	polymer	26	2859.2	2	UniProt (Q14457) Pfam (PF15285)	Homo sapiens	Coiled-coil myosin-like BCL2-interacting protein,Protein GT197
3	E, F, G (A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
4	H, I, J, K (A, B, C, D)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A, B: 1 - 26 (UniProt: Q07817)

PDB	External Database	Details
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

A, B: 83 - 208 (UniProt: Q07817)
C, D: 105 - 130 (UniProt: Q14457)

PDB	External Database	Details
Asp 108	Thr 108	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	41125.8
Non-Polymers*	Number of molecules	3
	Total formula weight	106.4
All*	Total formula weight	41232.1

*Water molecules are not included.