6DAI
Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | WD repeat-containing protein 5 | polymer | 313 | 34391.0 | 1 | UniProt (P61964) Pfam (PF00400) In PDB | Homo sapiens (Human) | BMP2-induced 3-kb gene protein |
| 2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 3 | A | 6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1-methylindoline | non-polymer | 239.3 | 2 | Chemie (G2V) | |||
| 4 | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34391.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 634.9 | |
| All* | Total formula weight | 35025.9 |
