6DAF
2.4 Angstrom crystal structure of the F141L Ca/CaM:CaV1.2 IQ domain complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Calmodulin-1 | polymer | 148 | 16687.3 | 2 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (Human) | |
| 2 | B, D (C, D) | Voltage-dependent L-type calcium channel subunit alpha-1C | polymer | 37 | 4319.0 | 2 | UniProt (Q13936) | Homo sapiens (Human) | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2 |
| 3 | E, F, G, H, I... (A, B) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 4 | M, N, O (A, B, D) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 148 (UniProt: P0DP23)
C, D: 1611 - 1644 (UniProt: Q13936)
| PDB | External Database | Details |
|---|---|---|
| Leu 141 | Phe 142 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 1608 | - | expression tag |
| Asn 1609 | - | expression tag |
| Ala 1610 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 42012.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 320.6 | |
| All* | Total formula weight | 42333.2 |
