6DA4
JAK3 with Cyanamide CP10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK3 | polymer | 321 | 36543.7 | 1 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | B (A) | (Z)-1-{2,2-difluoro-6-[5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-4H-1,4-benzoxazin-4-yl}methanimine | non-polymer | 373.4 | 1 | Chemie (G4V) | |||
| 3 | C (A) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 812 - 1124 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Met 804 | - | expression tag |
| Gly 805 | - | expression tag |
| His 806 | - | expression tag |
| His 807 | - | expression tag |
| His 808 | - | expression tag |
| His 809 | - | expression tag |
| His 810 | - | expression tag |
| His 811 | - | expression tag |
| Ser 1048 | Cys 1048 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36543.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 373.4 | |
| All* | Total formula weight | 36917.0 |
