6D6U
Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Gamma-aminobutyric acid receptor subunit beta-2,Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 341 | 39521.7 | 2 | UniProt (P47870) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit beta-2,GABA(A) receptor subunit beta-2 |
| 2 | B, D (B, D) | Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 358 | 41061.2 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit alpha-1,GABA(A) receptor subunit alpha-1 |
| 3 | E (E) | Gamma-aminobutyric acid receptor subunit gamma-2,Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 394 | 45354.7 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit gamma-2,GABA(A) receptor subunit gamma-2 |
| 4 | F, H (I, L) | Kappa Fab Light Chain | polymer | 213 | 23505.9 | 2 | Mus musculus (house mouse) | ||
| 5 | G, I (J, K) | IgG2b Fab Heavy Chain | polymer | 454 | 49811.0 | 2 | Mus musculus (house mouse) | ||
| 6 | J, L (F, H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 8 | M (M) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 9 | N, S (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | O, T (A, C) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) PubChem (119) | |||
| 11 | AA, BA, DA, P, Q... (D, E, A, B, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 12 | CA (D) | ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate | non-polymer | 303.3 | 1 | Chemie (FYP) PubChem (3373) |
Sequence modifications
A, C: 1 - 307 (UniProt: P47870)
A, C: 315 - 341 (UniProt: P47870)
B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (UniProt: P14867)
E: 1 - 322 (UniProt: P18507)
E: 329 - 357 (UniProt: P18507)
A, C: 315 - 341 (UniProt: P47870)
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 309 | - | linker |
| Pro 310 | - | linker |
| Ala 311 | - | linker |
| Arg 312 | - | linker |
| Ala 313 | - | linker |
| Ala 314 | - | linker |
B, D: 320 - 358 (UniProt: P14867)
| PDB | External Database | Details |
|---|---|---|
| Ser 313 | - | linker |
| Gln 314 | - | linker |
| Pro 315 | - | linker |
| Ala 316 | - | linker |
| Arg 317 | - | linker |
| Ala 318 | - | linker |
| Ala 319 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp -36 | - | expression tag |
| Ser -35 | - | expression tag |
| His -34 | - | expression tag |
| Pro -33 | - | expression tag |
| Gln -32 | - | expression tag |
| Phe -31 | - | expression tag |
| Glu -30 | - | expression tag |
| Lys -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Ser -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ala -16 | - | expression tag |
| Trp -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Gln -11 | - | expression tag |
| Phe -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 323 | - | linker |
| Gln 324 | - | linker |
| Pro 325 | - | linker |
| Ala 326 | - | linker |
| Arg 327 | - | linker |
| Ala 328 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 353154.4 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3481.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 6792.7 | |
| All* | Total formula weight | 363428.2 |
