6D6U
Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Gamma-aminobutyric acid receptor subunit beta-2,Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 341 | 39521.7 | 2 | UniProt (P47870) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit beta-2,GABA(A) receptor subunit beta-2 |
| 2 | B, D (B, D) | Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 358 | 41061.2 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit alpha-1,GABA(A) receptor subunit alpha-1 |
| 3 | E (E) | Gamma-aminobutyric acid receptor subunit gamma-2,Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 394 | 45354.7 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit gamma-2,GABA(A) receptor subunit gamma-2 |
| 4 | F, H (I, L) | Kappa Fab Light Chain | polymer | 213 | 23505.9 | 2 | Mus musculus (house mouse) | ||
| 5 | G, I (J, K) | IgG2b Fab Heavy Chain | polymer | 454 | 49811.0 | 2 | Mus musculus (house mouse) | ||
| 6 | J, L (F, H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 8 | M (M) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 9 | N, S (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | O, T (A, C) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) | |||
| 11 | AA, BA, DA, P, Q... (D, E, A, B, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) | |||
| 12 | CA (D) | ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate | non-polymer | 303.3 | 1 | Chemie (FYP) |
Sequence modifications
A, C: 1 - 307 (UniProt: P47870)
A, C: 315 - 341 (UniProt: P47870)
B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (UniProt: P14867)
E: 1 - 322 (UniProt: P18507)
E: 329 - 357 (UniProt: P18507)
A, C: 315 - 341 (UniProt: P47870)
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 309 | - | linker |
| Pro 310 | - | linker |
| Ala 311 | - | linker |
| Arg 312 | - | linker |
| Ala 313 | - | linker |
| Ala 314 | - | linker |
B, D: 320 - 358 (UniProt: P14867)
| PDB | External Database | Details |
|---|---|---|
| Ser 313 | - | linker |
| Gln 314 | - | linker |
| Pro 315 | - | linker |
| Ala 316 | - | linker |
| Arg 317 | - | linker |
| Ala 318 | - | linker |
| Ala 319 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp -36 | - | expression tag |
| Ser -35 | - | expression tag |
| His -34 | - | expression tag |
| Pro -33 | - | expression tag |
| Gln -32 | - | expression tag |
| Phe -31 | - | expression tag |
| Glu -30 | - | expression tag |
| Lys -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Ser -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ala -16 | - | expression tag |
| Trp -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Gln -11 | - | expression tag |
| Phe -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 323 | - | linker |
| Gln 324 | - | linker |
| Pro 325 | - | linker |
| Ala 326 | - | linker |
| Arg 327 | - | linker |
| Ala 328 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 353154.4 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3481.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 6792.7 | |
| All* | Total formula weight | 363428.2 |
