6D6T
Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Gamma-aminobutyric acid receptor subunit beta-2,Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 341 | 39521.7 | 2 | UniProt (P47870) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | GABA(A) receptor subunit beta-2,GABA(A) receptor subunit beta-2 |
| 2 | B, D | Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 358 | 41061.2 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | GABA(A) receptor subunit alpha-1,GABA(A) receptor subunit alpha-1 |
| 3 | E | Human GABA-A receptor subunit gamma-2 | polymer | 366 | 40825.7 | 1 | Pfam (PF02931) UniProt (by SIFTS) (P18507) In PDB | Homo sapiens (Human) | |
| 4 | I, L | Kappa Fab Light Chain | polymer | 213 | 23505.9 | 2 | Mus musculus (house mouse) | ||
| 5 | J, K | IgG2b Fab Heavy Chain | polymer | 454 | 49811.0 | 2 | Mus musculus (house mouse) | ||
| 6 | F, H | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | G | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 8 | M | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 9 | E, A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 10 | A, C | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) | |||
| 11 | D, A, B | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) | |||
| 12 | D | ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate | non-polymer | 303.3 | 1 | Chemie (FYP) |
Sequence modifications
A, C: 1 - 307 (UniProt: P47870)
A, C: 315 - 341 (UniProt: P47870)
B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (UniProt: P14867)
A, C: 315 - 341 (UniProt: P47870)
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 309 | - | linker |
| Pro 310 | - | linker |
| Ala 311 | - | linker |
| Arg 312 | - | linker |
| Ala 313 | - | linker |
| Ala 314 | - | linker |
B, D: 320 - 358 (UniProt: P14867)
| PDB | External Database | Details |
|---|---|---|
| Ser 313 | - | linker |
| Gln 314 | - | linker |
| Pro 315 | - | linker |
| Ala 316 | - | linker |
| Arg 317 | - | linker |
| Ala 318 | - | linker |
| Ala 319 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 348625.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3481.2 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 7013.9 | |
| All* | Total formula weight | 359120.5 |
