6D6T

Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Gamma-aminobutyric acid receptor subunit beta-2,Gamma-aminobutyric acid receptor subunit beta-2	polymer	341	39521.7	2	UniProt (P47870) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (Human)	GABA(A) receptor subunit beta-2,GABA(A) receptor subunit beta-2
2	B, D (B, D)	Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1	polymer	358	41061.2	2	UniProt (P14867) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (Human)	GABA(A) receptor subunit alpha-1,GABA(A) receptor subunit alpha-1
3	E (E)	Human GABA-A receptor subunit gamma-2	polymer	366	40825.7	1	Pfam (PF02931) UniProt (by SIFTS) (P18507)	Homo sapiens (Human)
4	F, H (I, L)	Kappa Fab Light Chain	polymer	213	23505.9	2		Mus musculus (house mouse)
5	G, I (J, K)	IgG2b Fab Heavy Chain	polymer	454	49811.0	2		Mus musculus (house mouse)
6	J, L (F, H)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
7	K (G)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1397.2	1	In PDB GlyTouCan (G80966KZ)
8	M (M)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
9	EA, N, Y (E, A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
10	O, Z (A, C)	GAMMA-AMINO-BUTANOIC ACID	non-polymer		103.1	2	Chemie (ABU) PubChem (119)
11	BA, CA, DA, P, Q... (D, A, B)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	12	Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028)
12	AA (D)	ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate	non-polymer		303.3	1	Chemie (FYP) PubChem (3373)

Sequence modifications

A, C: 1 - 307 (UniProt: P47870)
A, C: 315 - 341 (UniProt: P47870)

PDB	External Database	Details
Ser 308	-	linker
Gln 309	-	linker
Pro 310	-	linker
Ala 311	-	linker
Arg 312	-	linker
Ala 313	-	linker
Ala 314	-	linker

B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (UniProt: P14867)

PDB	External Database	Details
Ser 313	-	linker
Gln 314	-	linker
Pro 315	-	linker
Ala 316	-	linker
Arg 317	-	linker
Ala 318	-	linker
Ala 319	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	348625.5
Branched	Number of molecules	4
	Total formula weight	3481.2
Non-Polymers*	Number of molecules	18
	Total formula weight	7013.9
All*	Total formula weight	359120.5

*Water molecules are not included.