6D5M

Ras:SOS:Ras in complex with a small molecule activator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	Q	GTPase HRas	polymer	167	18840.1	1	UniProt (P01112) Pfam (PF00071) In PDB	Homo sapiens (Human)	H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
2	R	GTPase HRas	polymer	167	18932.2	1	UniProt (P01112) Pfam (PF00071) In PDB	Homo sapiens (Human)	H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
3	S	Son of sevenless homolog 1	polymer	482	56589.8	1	UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB	Homo sapiens (Human)	SOS-1
4	Q	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5	Q	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	1	Chemie (GNP)
6	S	1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-(piperazin-1-yl)-1H-benzimidazole	non-polymer		372.9	1	Chemie (FW4)
7		water	water		18.0	954	Chemie (HOH)

Sequence modifications

Q: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Gly 0	-	expression tag
Ala 64	Tyr 64	conflict

R: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Gly 0	-	expression tag

S: 566 - 1046 (UniProt: Q07889)

PDB	External Database	Details
Gly 565	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	94362.2
Non-Polymers*	Number of molecules	3
	Total formula weight	919.4
All*	Total formula weight	95281.5

*Water molecules are not included.