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6D5H

Ras:SOS:Ras in complex with a small molecule activator

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AGTPase HRaspolymer16718856.11UniProt (P01112)
Pfam (PF00071)
In PDB
Homo sapiens (Human)H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
2BSon of sevenless homolog 1polymer48256589.81UniProt (Q07889)
Pfam (PF00618)
Pfam (PF00617)
In PDB
Homo sapiens (Human)SOS-1
3CGTPase HRaspolymer16718932.21UniProt (P01112)
Pfam (PF00071)
In PDB
Homo sapiens (Human)H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
4APHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERnon-polymer522.21Chemie (GNP)
5AMAGNESIUM IONnon-polymer24.31Chemie (MG)
6A, CCHLORIDE IONnon-polymer35.53Chemie (CL)
7B6-chloro-4-(2-chlorophenyl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazolenon-polymer483.41Chemie (FV7)
8BFORMIC ACIDnon-polymer46.05Chemie (FMT)
9BGLYCEROLnon-polymer92.12Chemie (GOL)
10waterwater18.01155Chemie (HOH)
Sequence modifications
A: 1 - 166 (UniProt: P01112)
PDBExternal DatabaseDetails
Gly 0-expression tag
Ala 64Tyr 64conflict
B: 566 - 1046 (UniProt: Q07889)
PDBExternal DatabaseDetails
Gly 565-expression tag
C: 1 - 166 (UniProt: P01112)
PDBExternal DatabaseDetails
Gly 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight94378.2
Non-Polymers*Number of molecules13
Total formula weight1550.6
All*Total formula weight95928.8
*Water molecules are not included.

217705

PDB entries from 2024-03-27

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