6D55
Ras:SOS:Ras in complex with a small molecule activator
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTPase HRas | polymer | 167 | 18856.1 | 1 | UniProt (P01112) Pfam (PF00071) In PDB | Homo sapiens (Human) | H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras |
2 | B | Son of sevenless homolog 1 | polymer | 482 | 56589.8 | 1 | UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB | Homo sapiens (Human) | SOS-1 |
3 | C | GTPase HRas | polymer | 167 | 18932.2 | 1 | UniProt (P01112) Pfam (PF00071) In PDB | Homo sapiens (Human) | H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras |
4 | A | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
6 | B | 6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)-1H-benzimidazole | non-polymer | 483.0 | 1 | Chemie (FWA) | |||
7 | B, C | FORMIC ACID | non-polymer | 46.0 | 6 | Chemie (FMT) | |||
8 | B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
9 | C | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
10 | water | water | 18.0 | 1165 | Chemie (HOH) |
Sequence modifications
A: 1 - 166 (UniProt: P01112)
B: 566 - 1046 (UniProt: Q07889)
C: 1 - 166 (UniProt: P01112)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Ala 64 | Tyr 64 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 565 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 94378.2 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1512.9 | |
All* | Total formula weight | 95891.0 |