6D3X
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Plasminogen | polymer | 246 | 27009.1 | 2 | UniProt (P00747) Pfam (PF00089) | Homo sapiens (Human) | microplasmin |
| 2 | C, D (C, D) | Trypsin inhibitor 1 | polymer | 14 | 1613.9 | 2 | UniProt (Q4GWU5) | Helianthus annuus | SFTI-1 |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 318 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 14 (UniProt: Q4GWU5)
| PDB | External Database | Details |
|---|---|---|
| Tyr 4 | Thr 43 | engineered mutation |
| Lys 7 | Ile 46 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57246.0 | |
| All* | Total formula weight | 57246.0 |
