6D27
Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prostaglandin D2 receptor 2, Endolysin chimera | polymer | 470 | 52228.7 | 1 | UniProt (Q9Y5Y4) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) UniProt (by SIFTS) (P00720) | Homo sapiens (Human) | Chemoattractant receptor-homologous molecule expressed on Th2 cells,G-protein coupled receptor 44,Lysis protein,Lysozyme,Muramidase |
| 2 | B, C, D, E, F... (A) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | I (A) | [(3R)-3-{[(4-fluorophenyl)sulfonyl](methyl)amino}-1,2,3,4-tetrahydro-9H-carbazol-9-yl]acetic acid | non-polymer | 416.5 | 1 | Chemie (FT4) | |||
| 4 | J (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | K, L (A) | OLEIC ACID | non-polymer | 282.5 | 2 | Chemie (OLA) | |||
| 6 | M, N (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 7 | O, P, Q, R (A) | S-1,2-PROPANEDIOL | non-polymer | 76.1 | 4 | Chemie (PGO) | |||
| 8 | S (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 9 | T (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 236 (UniProt: Q9Y5Y4)
A: 1246 - 1256 (UniProt: D9IEF7)
A: 1262 - 1362 (UniProt: D9IEF7)
A: 2238 - 2339 (UniProt: Q9Y5Y4)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ala 25 | Asn 25 | engineered mutation |
| Ala 204 | Val 204 | variant |
A: 1262 - 1362 (UniProt: D9IEF7)
| PDB | External Database | Details |
|---|---|---|
| Gly 1257 | - | insertion |
| Gly 1258 | - | insertion |
| Ser 1259 | - | insertion |
| Gly 1260 | - | insertion |
| Gly 1261 | - | insertion |
| Ala 1298 | Cys 97 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 1238 | - | insertion |
| Asp 1239 | - | insertion |
| Leu 1240 | - | insertion |
| Gly 1241 | - | insertion |
| Leu 1242 | - | insertion |
| Gln 1243 | - | insertion |
| His 1244 | - | insertion |
| Arg 1245 | - | insertion |
| Leu 2340 | - | expression tag |
| Glu 2341 | - | expression tag |
| Val 2342 | - | expression tag |
| Leu 2343 | - | expression tag |
| Phe 2344 | - | expression tag |
| Gln 2345 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52228.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2559.9 | |
| All* | Total formula weight | 54788.6 |
