6D26

Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipiprant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Prostaglandin D2 receptor 2, Endolysin chimera	polymer	470	52228.7	1	UniProt (Q9Y5Y4) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) UniProt (by SIFTS) (P00720) In PDB	Homo sapiens (Human)	Chemoattractant receptor-homologous molecule expressed on Th2 cells,G-protein coupled receptor 44,Lysis protein,Lysozyme,Muramidase
2	A	fevipiprant	non-polymer		426.4	1	Chemie (FSY)
3	A	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
4	A	SUCCINIC ACID	non-polymer		118.1	5	Chemie (SIN)
5	A	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
6	A	OLEIC ACID	non-polymer		282.5	1	Chemie (OLA)
7	A	S-1,2-PROPANEDIOL	non-polymer		76.1	1	Chemie (PGO)
8		water	water		18.0	3	Chemie (HOH)

Sequence modifications

A: 1 - 236 (UniProt: Q9Y5Y4)

PDB	External Database	Details
Gly 0	-	expression tag
Ala 25	Asn 25	engineered mutation
Ala 204	Val 204	variant

A: 1246 - 1256 (UniProt: D9IEF7)
A: 1262 - 1362 (UniProt: D9IEF7)

PDB	External Database	Details
Gly 1257	-	insertion
Gly 1258	-	insertion
Ser 1259	-	insertion
Gly 1260	-	insertion
Gly 1261	-	insertion
Ala 1298	Cys 97	engineered mutation

A: 2238 - 2339 (UniProt: Q9Y5Y4)

PDB	External Database	Details
Ala 1238	-	insertion
Asp 1239	-	insertion
Leu 1240	-	insertion
Gly 1241	-	insertion
Leu 1242	-	insertion
Gln 1243	-	insertion
His 1244	-	insertion
Arg 1245	-	insertion
Leu 2340	-	expression tag
Glu 2341	-	expression tag
Val 2342	-	expression tag
Leu 2343	-	expression tag
Phe 2344	-	expression tag
Gln 2345	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52228.7
Non-Polymers*	Number of molecules	18
	Total formula weight	2390.1
All*	Total formula weight	54618.9

*Water molecules are not included.