6D1Z
Crystal structure of Tyrosine-protein kinase receptor in complex with 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | High affinity nerve growth factor receptor | polymer | 320 | 36110.5 | 1 | UniProt (P04629) Pfam (PF07714) | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | B (A) | 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one | non-polymer | 246.3 | 1 | Chemie (FQD) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | 5-{[5-(6-aminopyridin-2-yl)-2-chlorobenzene-1-carbonyl]amino}-1-phenyl-1H-pyrazole-3-carboxamide | non-polymer | 432.9 | 1 | Chemie (FQM) | |||
| 5 | E (A) | water | water | 18.0 | 181 | Chemie (HOH) |
Sequence modifications
A: 479 - 796 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| Gly 477 | - | expression tag |
| Ser 478 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36110.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 771.2 | |
| All* | Total formula weight | 36881.7 |
