6D03
Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; one molecule of parasite ligand.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transferrin receptor protein 1 | polymer | 659 | 73940.5 | 2 | UniProt (P02786) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) | Homo sapiens (Human) | Trfr,T9,p90 |
| 2 | C, D (C, D) | Serotransferrin | polymer | 698 | 77153.9 | 2 | UniProt (P02787) Pfam (PF00405) | Homo sapiens (Human) | Transferrin,Beta-1 metal-binding globulin,Siderophilin |
| 3 | E (E) | Reticulocyte binding protein 2, putative | polymer | 820 | 96798.5 | 1 | UniProt (A5K736) | Plasmodium vivax | |
| 4 | F, G, H, I, K (F, G, H, I, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 5 | J (J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(2-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G74111ZR) | |||
| 6 | L, N (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 7 | M, O, T, Y (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 8 | P, R, U, W (C, D) | FE (III) ION | non-polymer | 55.8 | 4 | Chemie (FE) | |||
| 9 | Q, S, V, X (C, D) | CARBONATE ION | non-polymer | 60.0 | 4 | Chemie (CO3) |
Sequence modifications
A, B: 121 - 760 (UniProt: P02786)
C, D: -18 - 679 (UniProt: P02787)
E: 156 - 969 (UniProt: A5K736)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | - | expression tag |
| Asp 103 | - | expression tag |
| Pro 104 | - | expression tag |
| His 105 | - | expression tag |
| His 106 | - | expression tag |
| His 107 | - | expression tag |
| His 108 | - | expression tag |
| His 109 | - | expression tag |
| His 110 | - | expression tag |
| Ser 111 | - | expression tag |
| Ser 112 | - | expression tag |
| Gly 113 | - | expression tag |
| Ile 114 | - | expression tag |
| Glu 115 | - | expression tag |
| Gly 116 | - | expression tag |
| Arg 117 | - | expression tag |
| Gly 118 | - | expression tag |
| Glu 119 | - | expression tag |
| Phe 120 | - | expression tag |
| Ser 142 | Gly 142 | variant |
| PDB | External Database | Details |
|---|---|---|
| Val 429 | Ile 448 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly 150 | - | expression tag |
| Ala 151 | - | expression tag |
| Met 152 | - | expression tag |
| Gly 153 | - | expression tag |
| Ser 154 | - | expression tag |
| Met 155 | - | expression tag |
| Ser 168 | Ile 14 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 398987.2 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2546.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1428.4 | |
| All* | Total formula weight | 402962.1 |
