6CWY

Crystal structure of SUMO E1 in complex with an allosteric inhibitor

エンティティ

Entity ID	鎖名	説明	種類	鎖長	化学式量	分子数	データベース名(アクセス番号)	由来する生物種	エンティティの一般名
1	C	SUMO-activating enzyme subunit 1	polymer	346	38499.8	1	UniProt (Q9UBE0) Pfam (PF00899) In PDB	Homo sapiens (Human)	Ubiquitin-like 1-activating enzyme E1A
2	D	SUMO-activating enzyme subunit 2	polymer	660	73485.9	1	UniProt (Q9UBT2) Pfam (PF00899) Pfam (PF14732) Pfam (PF16195) In PDB	Homo sapiens (Human)	Anthracycline-associated resistance ARX,Ubiquitin-like 1-activating enzyme E1B,Ubiquitin-like modifier-activating enzyme 2
3	C	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	D	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	D	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	D	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
7	D	dimethyl (1S,2S,3R,4R)-1-[(1S)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate	non-polymer		421.5	1	Chemie (FHJ)
8		water	water		18.0	45	Chemie (HOH)

配列変更

D: 1 - 640 (UniProt: Q9UBT2)

PDB	外部データベース	詳細
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

非対称単位の内容

タンパク質・ 核酸鎖	鎖の数	2
	化学式量合計	111985.7
タンパク質・ 核酸・ 糖鎖以外*	分子数	9
	化学式量合計	1079.6
全て*	化学式量合計	113065.3

*水分子は含んでいません