6CWA

CRYSTAL STRUCTURE PHGDH IN COMPLEX WITH NADH AND 3-PHOSPHOGLYCERATE AT 1.77 A RESOLUTION

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	D-3-phosphoglycerate dehydrogenase	polymer	327	35055.3	2	UniProt (O43175) Pfam (PF00389) Pfam (PF02826)	Homo sapiens (Human)	3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase
2	C, E (A, B)	3-PHOSPHOGLYCERIC ACID	non-polymer		186.1	2	Chemie (3PG)
3	D, F (A, B)	1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE	non-polymer		665.4	2	Chemie (NAI) PubChem (16219774) PubChem (928) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (94865921) PubChem (94865923) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (124432988) PubChem (140875346) PubChem (11250888) PubChem (12309341) PubChem (124934831) PubChem (124934833) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875)
4	G, H (A, B)	water	water		18.0	311	Chemie (HOH)

Sequence modifications

A, B: 3 - 314 (UniProt: O43175)

PDB	External Database	Details
Ser -12	-	expression tag
Gly -11	-	expression tag
Val -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Gly -7	-	expression tag
Thr -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Ser 1	-	expression tag
Met 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70110.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1703.0
All*	Total formula weight	71813.5

*Water molecules are not included.