6CVE
Crystal structure of Mycobacterium tuberculosis dethiobiotin Synthetase in complex with cytidine triphosphate and 7,8-diaminopelargonic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-dependent dethiobiotin synthetase BioD | polymer | 235 | 23473.9 | 4 | UniProt (P9WPQ5) Pfam (PF13500) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | DTB synthetase,DTBS,Dethiobiotin synthase |
| 2 | E, I, M (A, C, D) | CYTIDINE-5'-TRIPHOSPHATE | non-polymer | 483.2 | 3 | Chemie (CTP) | |||
| 3 | F, J, N (A, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | G, K, L (B, C) | 7-(CARBOXYAMINO)-8-AMINO-NONANOIC ACID | non-polymer | 232.3 | 3 | Chemie (DSD) | |||
| 5 | H (B) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 761 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 226 (UniProt: P9WPQ5)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | initiating methionine |
| Gly -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93895.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2408.3 | |
| All* | Total formula weight | 96304.0 |
