6CUT
Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3S)-isopropylserine bound as the external aldimine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Tryptophan synthase beta chain 1 | polymer | 388 | 42361.4 | 4 | UniProt (Q8U093) Pfam (PF00291) In PDB | Pyrococcus furiosus | |
| 2 | A, B, C, D | (2S,3S)-3-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-methylpentanoic acid (non-preferred name) | non-polymer | 376.3 | 4 | Chemie (FEJ) | |||
| 3 | A, B, C, D | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 4 | water | water | 18.0 | 389 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 388 (UniProt: Q8U093)
| PDB | External Database | Details |
|---|---|---|
| Val 16 | Ile 16 | engineered mutation |
| Gly 17 | Glu 17 | engineered mutation |
| Pro 91 | Leu 91 | engineered mutation |
| Leu 95 | Phe 95 | engineered mutation |
| Ala 161 | Leu 161 | engineered mutation |
| Glu 173 | Val 173 | engineered mutation |
| Leu 274 | Phe 274 | engineered mutation |
| Ser 292 | Thr 292 | engineered mutation |
| Ala 384 | Val 384 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 169445.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1597.2 | |
| All* | Total formula weight | 171043.0 |
