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6CU9

Structure of human DNA polymerase beta complexed with 8-ClG in the template base paired with incoming non-hydrolyzable CTP and MANGANESE

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
DNA polymerase betapolymer33538241.71UniProt (P06746)
Pfam (PF14716)
Pfam (PF10391)
Pfam (PF14792)
Pfam (PF14791)
Homo sapiens (Human)
2B
(T)
DNA (5'-D(*CP*CP*GP*AP*CP*(CGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')polymer164878.61Homo sapiens
3C
(P)
DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3')polymer103085.01Homo sapiens
4D
(D)
DNA (5'-D(P*GP*TP*CP*GP*G)-3')polymer51536.01Homo sapiens
5E, F
(A)
MANGANESE (II) IONnon-polymer54.92Chemie (MN)
6G, H
(A)
SODIUM IONnon-polymer23.02Chemie (NA)
7I
(A)
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidinenon-polymer466.21Chemie (0KX)
8J, K, L, M
(A, T, P, D)
waterwater18.0168Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight47741.3
Non-Polymers*Number of molecules5
Total formula weight622.0
All*Total formula weight48363.4
*Water molecules are not included.

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PDB entries from 2025-06-11

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