6CTM
Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL(R-isomer), beta, gamma dTTP analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | T | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 16 | 4853.2 | 1 | Homo sapiens | ||
| 2 | P | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3') | polymer | 10 | 3045.0 | 1 | Homo sapiens | ||
| 3 | D | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 1 | Homo sapiens | ||
| 4 | A | DNA polymerase beta | polymer | 335 | 38283.8 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) In PDB | Homo sapiens (Human) | |
| 5 | P, A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | A | 5'-O-[(R)-{[(R)-[(R)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]thymidine | non-polymer | 514.6 | 1 | Chemie (FDJ) | |||
| 8 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 9 | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Leu 70 | Ala 70 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47717.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 655.8 | |
| All* | Total formula weight | 48373.8 |
