6CSB
V308E mutant of cytochrome P450 2D6 complexed with thioridazine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 2D6 | polymer | 479 | 53760.6 | 4 | UniProt (P10635) Pfam (PF00067) | Homo sapiens (Human) | CYPIID6,Cholesterol 25-hydroxylase,Cytochrome P450-DB1,Debrisoquine 4-hydroxylase |
| 2 | AA, E, L, T (D, A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | BA, CA, F, G, M... (D, A, B, C) | 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine | non-polymer | 370.6 | 8 | Chemie (RTZ) | |||
| 4 | H, P, X (A, B, C) | HEGA-10 | non-polymer | 379.5 | 3 | Chemie (2CV) | |||
| 5 | DA, I, J, K, Q... (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) | |||
| 6 | O (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 7 | W (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | EA, FA, GA, HA (A, B, C, D) | water | water | 18.0 | 546 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 34 - 497 (UniProt: P10635)
| PDB | External Database | Details |
|---|---|---|
| Met 23 | - | initiating methionine |
| Ala 24 | - | expression tag |
| Lys 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Thr 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Lys 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Lys 32 | - | expression tag |
| Leu 33 | - | expression tag |
| Glu 308 | Val 308 | engineered mutation |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 215042.2 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 7308.8 | |
| All* | Total formula weight | 222351.0 |
