6CPW
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 1 | polymer | 366 | 42361.7 | 1 | UniProt (P63086) Pfam (PF00069) In PDB | Rattus norvegicus (Rat) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
3 | A | (3S)-N-[3-(4-fluorophenyl)-1H-indazol-5-yl]-3-(methylsulfanyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidine-3-carboxamide | non-polymer | 650.8 | 1 | Chemie (F8V) | |||
4 | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A: 1 - 358 (UniProt: P63086)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Ala -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42361.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 842.9 | |
All* | Total formula weight | 43204.6 |