6CNP

Crystal structure of MBD2 complex with methylated CpG island

Replaces:  6C2K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methyl-CpG-binding domain protein 2	polymer	96	10934.5	2	UniProt (Q9UBB5) Pfam (PF01429)	Homo sapiens (Human)	Demethylase,DMTase,Methyl-CpG-binding protein MBD2
2	C, D, E, F (C, D, E, F)	DNA (5'-D(*GP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*C)-3')	polymer	12	3678.4	4		synthetic construct
3	G (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
4	H, I, J, K, L... (A, B, E, F)	UNKNOWN ATOM OR ION	non-polymer			11	Chemie (UNX)
5	S, T, U, V, W... (A, B, C, D, E...)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

A, B: 143 - 220 (UniProt: Q9UBB5)

PDB	External Database	Details
Met 125	-	initiating methionine
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
Ser 132	-	expression tag
Ser 133	-	expression tag
Gly 134	-	expression tag
Arg 135	-	expression tag
Glu 136	-	expression tag
Asn 137	-	expression tag
Leu 138	-	expression tag
Tyr 139	-	expression tag
Phe 140	-	expression tag
Gln 141	-	expression tag
Gly 142	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	36582.6
Non-Polymers*	Number of molecules	12
	Total formula weight	40.1
All*	Total formula weight	36622.7

*Water molecules are not included.