6CM3
BG505 SOSIP in complex with sCD4, 17b, 8ANC195
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Envelope glycoprotein gp160 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S7) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | D, E, F | Envelope glycoprotein gp160 | polymer | 481 | 54064.3 | 3 | UniProt (Q2N0S5) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | G, H, I | T-cell surface glycoprotein CD4 | polymer | 192 | 21472.3 | 3 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) In PDB | Homo sapiens (Human) | T-cell surface antigen T4/Leu-3 |
| 4 | J, L, N | 17b Fab light chain | polymer | 214 | 23399.9 | 3 | Homo sapiens (Human) | ||
| 5 | K, M, O | 17b Fab heavy chain | polymer | 229 | 24457.4 | 3 | Homo sapiens (Human) | ||
| 6 | P, R, T | 8ANC195 Fab heavy chain | polymer | 244 | 26125.3 | 3 | Homo sapiens (Human) | ||
| 7 | Q, S, U | 8ANC195 Fab light chain | polymer | 215 | 23402.0 | 3 | Homo sapiens (Human) | ||
| 8 | b, f, j, V, W... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 9 | c, g, Y | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 3 | In PDB GlyTouCan (G40702WU) | |||
| 10 | d, h, Z | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G42227JK) | |||
| 11 | a, e, i | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 12 | F, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
A, B, C: 512 - 664 (UniProt: Q2N0S7)
D, E, F: 31 - 511 (UniProt: Q2N0S5)
G, H, I: 1 - 182 (UniProt: P01730)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | conflict |
| Cys 501 | Ala 498 | conflict |
| Arg 509 | Glu 506 | conflict |
| Arg 510 | Lys 507 | conflict |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 183 | - | expression tag |
| Asp 184 | - | expression tag |
| Gly 185 | - | expression tag |
| Arg 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| His 190 | - | expression tag |
| His 191 | - | expression tag |
| His 192 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 570202.9 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 13175.9 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 587360.6 |
