6CKI
Co-crystal structure of MNK2 in Complex With Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | MAP kinase-interacting serine/threonine-protein kinase 2 | polymer | 316 | 35604.5 | 1 | UniProt (Q9HBH9) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAP kinase signal-integrating kinase 2,Mnk2 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | 3,3-dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione | non-polymer | 271.3 | 1 | Chemie (FZJ) | |||
4 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 72 - 385 (UniProt: Q9HBH9)
PDB | External Database | Details |
---|---|---|
Gly 70 | - | expression tag |
Ser 71 | - | expression tag |
Gly 228 | Asp 228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35604.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 336.7 | |
All* | Total formula weight | 35941.1 |