6CJH
Co-crystal structure of MNK2 in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MAP kinase-interacting serine/threonine-protein kinase 2 | polymer | 316 | 35604.5 | 1 | UniProt (Q9HBH9) Pfam (PF00069) | Homo sapiens (Human) | MAP kinase signal-integrating kinase 2,Mnk2 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 3-phenyl-5-(pyridin-4-yl)-1H-indazole | non-polymer | 271.3 | 1 | Chemie (ET8) |
Sequence modifications
A: 72 - 385 (UniProt: Q9HBH9)
| PDB | External Database | Details |
|---|---|---|
| Gly 70 | - | expression tag |
| Ser 71 | - | expression tag |
| Gly 228 | Asp 228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35604.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 336.7 | |
| All* | Total formula weight | 35941.2 |
