6CIR
Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 oxime
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Steroid 17-alpha-hydroxylase/17,20 lyase | polymer | 494 | 55740.1 | 4 | UniProt (P05093) Pfam (PF00067) In PDB | Homo sapiens (Human) | 17-alpha-hydroxyprogesterone aldolase,CYPXVII,Cytochrome P450 17A1,Cytochrome P450-C17,Cytochrome P450c17,Steroid 17-alpha-monooxygenase |
| 2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | A, B, C, D | 6-oxime-17-(3-pyridyl)-androst-16-en-3-ol | non-polymer | 380.5 | 4 | Chemie (3NQ) | |||
| 4 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 508 (UniProt: P05093)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | initiating methionine |
| Ala 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Lys 22 | - | expression tag |
| Thr 23 | - | expression tag |
| His 509 | - | expression tag |
| His 510 | - | expression tag |
| His 511 | - | expression tag |
| His 512 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 222960.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3988.0 | |
| All* | Total formula weight | 226948.6 |
