6CHB
Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, M (B, A, C) | Envelope glycoprotein gp41 | polymer | 153 | 17162.5 | 3 | UniProt (Q2N0S7) Pfam (PF00517) UniProt (by SIFTS) (Q2N0S5) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, H, N (G, F, H) | Envelope glycoprotein gp120 | polymer | 479 | 53693.8 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | C, K, Q (J, I, Q) | BG18 Heavy Chain | polymer | 241 | 26158.4 | 3 | Homo sapiens (Human) | ||
| 4 | D, L, R (K, L, R) | BG18 Light Chain | polymer | 215 | 23021.4 | 3 | Homo sapiens (Human) | ||
| 5 | E, I, O (D, M, O) | IOMA Heavy Chain | polymer | 232 | 25176.4 | 3 | Homo sapiens (Human) | ||
| 6 | F, J, P (E, N, P) | IOMA Light Chain | polymer | 214 | 22592.0 | 3 | Homo sapiens (Human) |
Sequence modifications
B, A, C: 512 - 664 (UniProt: Q2N0S7)
G, F, H: 31 - 511 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Cys 605 | Thr 602 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | conflict |
| Cys 501 | Ala 498 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 503413.6 | |
| All* | Total formula weight | 503413.6 |
