6CH9
Crystal structure of a natively-glycosylated B41 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Envelope glycoprotein gp41 | polymer | 153 | 17357.8 | 1 | UniProt (B3UEZ6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
2 | D | 35O22 Heavy Chain | polymer | 243 | 26171.5 | 1 | Homo sapiens (Human) | ||
3 | E | 35O22 Light Chain | polymer | 216 | 23318.8 | 1 | Homo sapiens (Human) | ||
4 | G | Envelope glycoprotein gp120 | polymer | 518 | 57929.7 | 1 | UniProt (B3UES2) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
5 | Q | BG18 Heavy Chain | polymer | 240 | 26020.2 | 1 | Homo sapiens (Human) | ||
6 | R | BG18 Light Chain | polymer | 215 | 23021.4 | 1 | Homo sapiens (Human) | ||
7 | A, C, H, J, O... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 7 | In PDB GlyTouCan (G15407YE) | |||
8 | F | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
9 | I, K, N | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
10 | L | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
11 | M | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
12 | S | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
13 | U | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G00850LT) | |||
14 | B, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
B: 512 - 664 (UniProt: B3UEZ6)
G: 31 - 507 (UniProt: B3UES2)
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 563 | conflict |
Cys 605 | Thr 609 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Lys 0 | - | expression tag |
Arg 1 | - | expression tag |
Gly 2 | - | expression tag |
Leu 3 | - | expression tag |
Cys 4 | - | expression tag |
Cys 5 | - | expression tag |
Val 6 | - | expression tag |
Leu 7 | - | expression tag |
Leu 8 | - | expression tag |
Leu 9 | - | expression tag |
Cys 10 | - | expression tag |
Gly 11 | - | expression tag |
Ala 12 | - | expression tag |
Val 13 | - | expression tag |
Phe 14 | - | expression tag |
Val 15 | - | expression tag |
Ser 16 | - | expression tag |
Pro 17 | - | expression tag |
Ser 18 | - | expression tag |
Gln 19 | - | expression tag |
Glu 20 | - | expression tag |
Ile 21 | - | expression tag |
His 22 | - | expression tag |
Ala 23 | - | expression tag |
Arg 24 | - | expression tag |
Phe 25 | - | expression tag |
Arg 26 | - | expression tag |
Arg 27 | - | expression tag |
Gly 28 | - | expression tag |
Ala 29 | - | expression tag |
Arg 30 | - | expression tag |
Cys 501 | Ala 505 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 173819.6 | |
Branched | Number of molecules | 15 |
Total formula weight | 9933.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 884.8 | |
All* | Total formula weight | 184637.5 |