6CFP

CRYSTAL STRUCTURE OF POLYMERASE ACID PROTEIN (PA) FROM INFLUENZA A VIRUS, WILSON-SMITH/1933 (H1N1) BOUND TO FRAGMENT HIT BSI-70565 1-{1-[4-FLUOROPHENYL)METHYL]-2-METHYL-1H-IMIDAZOL-4-YL}ETHAN-1-ONE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ubiquitin-like protein SMT3,Polymerase acidic protein	polymer	559	64144.2	1	UniProt (Q12306) UniProt (P15659) Pfam (PF00240) Pfam (PF00603)	Saccharomyces cerevisiae (Baker's yeast)	RNA-directed RNA polymerase subunit P2
2	B (A)	1-{1-[(4-fluorophenyl)methyl]-2-methyl-1H-imidazol-4-yl}ethan-1-one	non-polymer		232.3	1	Chemie (EZS)
3	C (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4	D (A)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A: 168 - 253 (UniProt: Q12306)

PDB	External Database	Details
Met 158	-	initiating methionine
Gly 159	-	expression tag
His 160	-	expression tag
His 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
Ser 166	-	expression tag
Gly 167	-	expression tag

A: 254 - 716 (UniProt: P15659)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	64144.2
Non-Polymers*	Number of molecules	2
	Total formula weight	310.4
All*	Total formula weight	64454.6

*Water molecules are not included.