6CES
Cryo-EM structure of GATOR1-RAG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | N | GATOR complex protein NPRL2 | polymer | 380 | 43711.4 | 1 | UniProt (Q8WTW4) Pfam (PF06218) In PDB | Homo sapiens (Human) | Gene 21 protein,G21 protein,Nitrogen permease regulator 2-like protein,NPR2-like protein,Tumor suppressor candidate 4 |
| 2 | M | GATOR complex protein NPRL3 | polymer | 569 | 63680.8 | 1 | UniProt (Q12980) Pfam (PF03666) In PDB | Homo sapiens (Human) | -14 gene protein,Alpha-globin regulatory element-containing gene protein,Nitrogen permease regulator 3-like protein,Protein CGTHBA |
| 3 | D | GATOR complex protein DEPDC5 | polymer | 1603 | 181478.0 | 1 | UniProt (O75140) Pfam (PF23013) Pfam (PF12257) Pfam (PF00610) Pfam (PF19418) In PDB | Homo sapiens (Human) | DEP domain-containing protein 5 |
| 4 | A | Ras-related GTP-binding protein A | polymer | 313 | 36615.2 | 1 | UniProt (Q7L523) Pfam (PF04670) In PDB | Homo sapiens (Human) | RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1 |
| 5 | C | Ras-related GTP-binding protein C | polymer | 399 | 44298.9 | 1 | UniProt (Q9HB90) Pfam (PF04670) In PDB | Homo sapiens (Human) | RagC,GTPase-interacting protein 2,TIB929 |
| 6 | A | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) |
Sequence modifications
C: 1 - 399 (UniProt: Q9HB90)
| PDB | External Database | Details |
|---|---|---|
| Asn 75 | Ser 75 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 369784.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 522.2 | |
| All* | Total formula weight | 370306.4 |
