6CE9
Insulin Receptor ectodomain in complex with two insulin molecules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin receptor | polymer | 917 | 104736.8 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) | Homo sapiens (Human) | IR |
| 2 | C, H (M, P) | Insulin receptor | polymer | 30 | 3671.2 | 2 | UniProt (P06213) | Homo sapiens (Human) | IR |
| 3 | D, F (K, N) | Insulin A chain | polymer | 21 | 2383.7 | 2 | UniProt (P01308) | Homo sapiens | |
| 4 | E, G (L, O) | Insulin B chain | polymer | 30 | 3403.9 | 2 | UniProt (P01318) Pfam (PF00049) | Ovis aries | |
| 5 | I, K, N, P (C, E, H, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 4 | In PDB GlyTouCan (G21290RB) | |||
| 6 | J, O (D, I) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | L, Q (F, Q) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | M, R (G, R) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 9 | S, T, U, V (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B: 1 - 917 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 228391.3 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5038.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 234314.8 |
