6CCV
Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Rifampicin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, K (A, B, T) | DNA-directed RNA polymerase subunit alpha | polymer | 350 | 37959.4 | 3 | UniProt (A0QSL8) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha |
| 2 | C (C) | DNA-directed RNA polymerase subunit beta | polymer | 1169 | 128680.1 | 1 | UniProt (P60281) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta |
| 3 | D (D) | DNA-directed RNA polymerase subunit beta' | polymer | 1317 | 146712.9 | 1 | UniProt (A0QS66) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta' |
| 4 | E (E) | DNA-directed RNA polymerase subunit omega | polymer | 107 | 11544.8 | 1 | UniProt (A0QWT1) Pfam (PF01192) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega |
| 5 | F (F) | RNA polymerase sigma factor SigA | polymer | 466 | 51573.6 | 1 | UniProt (A0QW02) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 6 | G (G) | Unknown Peptide | polymer | 17 | 1464.8 | 1 | Mycobacterium smegmatis str. MC2 155 | ||
| 7 | H (J) | RNA polymerase-binding protein RbpA | polymer | 114 | 13078.7 | 1 | UniProt (A0QZ11) Pfam (PF13397) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 8 | I (O) | DNA (31-MER) | polymer | 31 | 9565.2 | 1 | synthetic construct | ||
| 9 | J (P) | DNA (26-MER) | polymer | 26 | 7930.2 | 1 | synthetic construct | ||
| 10 | BA, EA, FA, GA, HA... (D, F, C) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 11 | AA, CA, IA, JA, O... (D, F, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 12 | P (C) | RIFAMPICIN | non-polymer | 822.9 | 1 | Chemie (RFP) PubChem (176795423) PubChem (135403807) PubChem (135398735) PubChem (135441414) PubChem (135499655) PubChem (135484647) PubChem (135449527) PubChem (135484654) PubChem (135512673) PubChem (135671118) PubChem (135678740) PubChem (135603898) PubChem (135583296) PubChem (135762817) PubChem (135665293) PubChem (135889899) PubChem (135802250) PubChem (135887800) PubChem (135921123) PubChem (135857107) PubChem (135876149) PubChem (135887798) PubChem (135925261) PubChem (135900090) PubChem (135972658) PubChem (135928731) PubChem (136023866) PubChem (136136478) PubChem (136122621) PubChem (136170985) PubChem (136238056) PubChem (136257952) PubChem (136226255) PubChem (136254574) PubChem (136504372) PubChem (136653818) PubChem (136619758) PubChem (137007092) PubChem (136594454) PubChem (136621208) PubChem (136646928) PubChem (137097436) PubChem (137097438) PubChem (137086834) PubChem (137091153) PubChem (137108668) PubChem (137191444) PubChem (137154388) PubChem (137184359) PubChem (137154390) PubChem (137159087) PubChem (137177954) PubChem (137229761) PubChem (137222345) PubChem (137208337) PubChem (137218464) PubChem (137267378) PubChem (137286743) PubChem (137704761) PubChem (138106897) PubChem (153274061) PubChem (154075449) PubChem (155556302) PubChem (162984936) PubChem (163059759) PubChem (165729089) PubChem (171360673) PubChem (171686453) PubChem (171699545) PubChem (172916695) PubChem (172995356) PubChem (173717570) PubChem (175653389) PubChem (135476790) PubChem (135550179) PubChem (135582338) PubChem (135584810) PubChem (135665270) PubChem (135738853) PubChem (135781042) PubChem (135802251) PubChem (135814583) PubChem (135822715) PubChem (135887799) PubChem (135889901) PubChem (135915642) PubChem (135921134) PubChem (135925249) PubChem (135925741) PubChem (135932822) PubChem (136153113) PubChem (136246612) PubChem (136250494) PubChem (136257946) PubChem (136257949) PubChem (136265302) PubChem (136598085) PubChem (136601293) PubChem (136620716) PubChem (136631923) PubChem (136709103) PubChem (137016821) PubChem (137091122) PubChem (137092548) PubChem (137092933) PubChem (137097437) PubChem (137097439) PubChem (137138798) PubChem (137154389) PubChem (137154391) PubChem (137169073) PubChem (137208355) PubChem (137225336) PubChem (137229762) PubChem (137251213) PubChem (137270779) PubChem (137270910) PubChem (138756139) PubChem (162984937) PubChem (171336500) PubChem (172966639) PubChem (172987825) PubChem (173493550) | |||
| 13 | S, T (D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 14 | DA (D) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) | |||
| 15 | KA, LA, MA (C, D, F) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 484428.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2846.3 | |
| All* | Total formula weight | 487274.8 |
