6CCF
Crystal Structure of the Human CAMKK1A in complex with Hesperadin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Calcium/calmodulin-dependent protein kinase kinase 1 | polymer | 290 | 32702.7 | 2 | UniProt (Q8N5S9) Pfam (PF00069) | Homo sapiens (Human) | CaMKK 1, CaM-kinase IV kinase, Calcium/calmodulin-dependent protein kinase kinase alpha, CaMKK alpha |
| 2 | C, E (A, B) | N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE | non-polymer | 516.7 | 2 | Chemie (H1N) | |||
| 3 | D (A) | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 4 | F (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
A, B: 124 - 411 (UniProt: Q8N5S9)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | - | expression tag |
| Met 123 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65405.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1153.5 | |
| All* | Total formula weight | 66558.9 |
