6C9D

Crystal structure of KA1-autoinhibited MARK1 kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Serine/threonine-protein kinase MARK1,Serine/threonine-protein kinase MARK1	polymer	459	52936.7	2	UniProt (Q9P0L2) Pfam (PF00069) Pfam (PF00627) Pfam (PF02149) In PDB	Homo sapiens (Human)	MAP/microtubule affinity-regulating kinase 1, PAR1 homolog c, Par1c
2		water	water		18.0	68	Chemie (HOH)

Sequence modifications

A, B: 45 - 381 (UniProt: Q9P0L2)

PDB	External Database	Details
Met 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
His 44	-	expression tag
Glu 215	Thr 215	engineered mutation

A, B: 681 - 795 (UniProt: Q9P0L2)

PDB	External Database	Details
Ser 761	Lys 761	engineered mutation
Ser 764	Arg 764	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105873.4
All*	Total formula weight	105873.4

*Water molecules are not included.