6C83
Structure of Aurora A (122-403) bound to inhibitory Monobody Mb2 and AMPPCP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aurora kinase A | polymer | 285 | 32990.8 | 2 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | C, D (C, D) | Mb2 Monobody | polymer | 93 | 9854.0 | 2 | synthetic construct | ||
| 3 | E, F (A, B) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 2 | Chemie (ACP) |
Sequence modifications
A, B: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ser 119 | - | expression tag |
| Val 120 | - | expression tag |
| Asp 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 85689.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1010.4 | |
| All* | Total formula weight | 86699.9 |
