6C7Z

Crystal structure of the Q108K:K40L:T51V:R58F mutant of human Cellular Retinol Binding Protein II in complex with synthetic Ligand Julolidine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Retinol-binding protein 2	polymer	133	15570.5	2	UniProt (P50120) Pfam (PF00061) In PDB	Homo sapiens (Human)	Cellular retinol-binding protein II,CRBP-II
2	A, B	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
3	A, B	(2E,4E)-3-methyl-5-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)penta-2,4-dienal	non-polymer		267.4	2	Chemie (JLO)
4		water	water		18.0	194	Chemie (HOH)

Sequence modifications

A, B: 1 - 133 (UniProt: P50120)

PDB	External Database	Details
Leu 40	Lys 41	engineered mutation
Val 51	Thr 52	engineered mutation
Phe 58	Arg 59	engineered mutation
Lys 108	Gln 109	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31141.0
Non-Polymers*	Number of molecules	4
	Total formula weight	652.8
All*	Total formula weight	31793.8

*Water molecules are not included.