6C7G
Crystal structure of human phosphodiesterase 2A with N-(1-adamantyl)-1-(2-chloro-5-isobutoxy-phenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 342 | 39909.8 | 4 | UniProt (O00408) Pfam (PF00233) In PDB | Homo sapiens (Human) | Cyclic GMP-stimulated phosphodiesterase, cGSPDE |
| 2 | A, B, C, D | 1-[2-chloro-5-(2-methylpropoxy)phenyl]-4-methyl-N-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl][1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | non-polymer | 544.1 | 4 | Chemie (EOY) | |||
| 3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 676 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 579 - 917 (UniProt: O00408)
| PDB | External Database | Details |
|---|---|---|
| Ser 576 | - | expression tag |
| Ala 577 | - | expression tag |
| Met 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 159639.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2535.2 | |
| All* | Total formula weight | 162174.5 |
