6C2W
Crystal structure of human prothrombin mutant S101C/A470C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Prothrombin | polymer | 582 | 66309.9 | 2 | UniProt (P00734) Pfam (PF00594) Pfam (PF00051) Pfam (PF09396) Pfam (PF00089) | Homo sapiens (Human) | Coagulation factor II |
| 2 | C, D (C, D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 2 | In PDB GlyTouCan (G90333CG) | |||
| 3 | E, F, G, H, I... (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 12 | Chemie (MG) | |||
| 4 | K, R (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A, B: 1 - 579 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Cys 101 | Ser 144 | engineered mutation |
| Met 122 | Thr 165 | variant |
| Cys 470 | Ala 513 | engineered mutation |
| Tyr 580 | - | expression tag |
| Leu 581 | - | expression tag |
| Glu 582 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 132619.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 766.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 734.1 | |
| All* | Total formula weight | 134120.5 |
