6C0W
Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3-like centromeric protein A | polymer | 140 | 16023.6 | 2 | UniProt (P49450) Pfam (PF00125) | Homo sapiens (Human) | Centromere autoantigen A,Centromere protein A,CENP-A |
| 2 | B, F (B, F) | Histone H4 | polymer | 102 | 11337.4 | 2 | UniProt (P62805) Pfam (PF15511) | Homo sapiens (Human) | |
| 3 | C, G (C, G) | Histone H2A | polymer | 130 | 14135.5 | 2 | UniProt (Q93077) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (Human) | Histone H2A/l |
| 4 | D, H (D, H) | Histone H2B | polymer | 126 | 13937.2 | 2 | UniProt (P62807) Pfam (PF00125) | Homo sapiens (Human) | Histone H2B.1 A, Histone H2B.a, H2B/a, Histone H2B.g, H2B/g, Histone H2B.h, H2B/h, Histone H2B.k, H2B/k, Histone H2B.l, H2B/l |
| 5 | I (I) | 147 mer DNA | polymer | 147 | 45153.8 | 1 | Escherichia coli | ||
| 6 | J (J) | 147 mer DNA | polymer | 147 | 45594.0 | 1 | Escherichia coli | ||
| 7 | K (K) | Centromere protein N | polymer | 295 | 34870.7 | 1 | UniProt (Q96H22) Pfam (PF05238) | Homo sapiens (Human) | CENP-N, Interphase centromere complex protein 32 |
Sequence modifications
K: 1 - 289 (UniProt: Q96H22)
| PDB | External Database | Details |
|---|---|---|
| Asp 84 | Glu 84 | variant |
| His 290 | - | expression tag |
| His 291 | - | expression tag |
| His 292 | - | expression tag |
| His 293 | - | expression tag |
| His 294 | - | expression tag |
| His 295 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 236486.0 | |
| All* | Total formula weight | 236486.0 |
