6BXH
Menin in complex with MI-853
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Menin | polymer | 509 | 56626.5 | 1 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (Human) | |
| 2 | B (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | 1-{2-[4-(fluoroacetyl)piperazin-1-yl]ethyl}-4-methyl-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile | non-polymer | 656.7 | 1 | Chemie (EE7) | |||
| 5 | E (A) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 1 - 459 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Glu 387 | deletion |
| - | Glu 388 | deletion |
| - | Arg 389 | deletion |
| - | Pro 390 | deletion |
| - | Gly 391 | deletion |
| - | Glu 392 | deletion |
| - | Gln 393 | deletion |
| - | Ser 394 | deletion |
| - | Gln 395 | deletion |
| - | Gly 396 | deletion |
| - | Thr 397 | deletion |
| - | Gln 398 | deletion |
| Val 460 | - | expression tag |
| Pro 461 | - | expression tag |
| Ala 539 | - | expression tag |
| Pro 540 | - | expression tag |
| Ala 541 | - | expression tag |
| Ala 542 | - | expression tag |
| Ser 543 | - | expression tag |
| Pro 544 | - | expression tag |
| Pro 545 | - | expression tag |
| Pro 546 | - | expression tag |
| Glu 547 | - | expression tag |
| Gly 548 | - | expression tag |
| Pro 549 | - | expression tag |
| Val 550 | - | expression tag |
| Leu 551 | - | expression tag |
| Thr 552 | - | expression tag |
| Phe 553 | - | expression tag |
| Gln 554 | - | expression tag |
| Ser 555 | - | expression tag |
| Glu 556 | - | expression tag |
| Lys 557 | - | expression tag |
| Met 558 | - | expression tag |
| Lys 559 | - | expression tag |
| Gly 560 | - | expression tag |
| Met 561 | - | expression tag |
| Lys 562 | - | expression tag |
| Glu 563 | - | expression tag |
| Leu 564 | - | expression tag |
| Leu 565 | - | expression tag |
| Val 566 | - | expression tag |
| Ala 567 | - | expression tag |
| Thr 568 | - | expression tag |
| Lys 569 | - | expression tag |
| Ile 570 | - | expression tag |
| Asn 571 | - | expression tag |
| Ser 572 | - | expression tag |
| Ser 573 | - | expression tag |
| Ala 574 | - | expression tag |
| Ile 575 | - | expression tag |
| Lys 576 | - | expression tag |
| Leu 577 | - | expression tag |
| Gln 578 | - | expression tag |
| Leu 579 | - | expression tag |
| Thr 580 | - | expression tag |
| Ala 581 | - | expression tag |
| Gln 582 | - | expression tag |
| Ser 583 | - | expression tag |
| Gln 584 | - | expression tag |
| Val 585 | - | expression tag |
| Gln 586 | - | expression tag |
| Met 587 | - | expression tag |
| Lys 588 | - | expression tag |
| Lys 589 | - | expression tag |
| Gln 590 | - | expression tag |
| Lys 591 | - | expression tag |
| Val 592 | - | expression tag |
| Ser 593 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56626.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 830.9 | |
| All* | Total formula weight | 57457.4 |
