6BVM

Ras:SOS:Ras in complex with a small molecule activator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GTPase HRas	polymer	167	18856.1	1	UniProt (P01112) Pfam (PF00071) In PDB	Homo sapiens (Human)	H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
2	B	Son of sevenless homolog 1	polymer	482	56589.8	1	UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB	Homo sapiens (Human)
3	C	GTPase HRas	polymer	167	18932.2	1	UniProt (P01112) Pfam (PF00071) In PDB	Homo sapiens (Human)	H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
4	A	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	1	Chemie (GNP)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	B	(2S)-2-amino-1-[(3aR,6aS)-5-[(5-chloro-1H-indol-3-yl)methyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-3-(1H-indol-3-yl)propan-1-one	non-polymer		462.0	1	Chemie (EBV)
7	B, C	FORMIC ACID	non-polymer		46.0	6	Chemie (FMT)
8	B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
9	C	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
10		water	water		18.0	1167	Chemie (HOH)

Sequence modifications

A: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Gly 0	-	expression tag
Ala 64	Tyr 64	engineered mutation

B: 566 - 1046 (UniProt: Q07889)

PDB	External Database	Details
Gly 565	-	expression tag

C: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	94378.2
Non-Polymers*	Number of molecules	12
	Total formula weight	1491.8
All*	Total formula weight	95870.0

*Water molecules are not included.