6BSH

Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	REVERSE TRANSCRIPTASE P66 SUBUNIT	polymer	558	64126.4	1	UniProt (P03367) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) UniProt (by SIFTS) (P04585) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)	Pr160Gag-Pol
2	B	REVERSE TRANSCRIPTASE P51 SUBUNIT	polymer	441	51384.0	1	UniProt (A0A076Q3N8) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) UniProt (by SIFTS) (P04585) In PDB	Human immunodeficiency virus 1
3	D	DNA (5'-D(*GP*TP*AP*TP*GP*CP*CP*AP*CP*TP*AP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3')	polymer	23	7062.6	1		Homo sapiens
4	R	RNA (25-MER)	polymer	25	7919.8	1		Homo sapiens
5	A	(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE	non-polymer		315.7	1	Chemie (EFZ)
6	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
7	A, B, D	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
8	R	TRIS(HYDROXYETHYL)AMINOMETHANE	non-polymer		163.2	1	Chemie (TAM)
9		water	water		18.0	115	Chemie (HOH)

Sequence modifications

A: 1 - 557 (UniProt: P03367)

PDB	External Database	Details
Gly 0	-	expression tag
Gly 68	Ser 667	conflict
Lys 83	Arg 682	conflict
Met 357	Thr 956	conflict
Val 411	Ile 1010	conflict
Lys 461	Arg 1060	conflict
Gln 512	Lys 1111	conflict

B: 1 - 440 (UniProt: A0A076Q3N8)

PDB	External Database	Details
Gly 0	-	expression tag
Gly 68	Ser 235	conflict
Lys 83	Arg 250	conflict
Val 411	Ile 578	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130492.8
Non-Polymers*	Number of molecules	10
	Total formula weight	1111.6
All*	Total formula weight	131604.4

*Water molecules are not included.