6BRA
HIV-1 protease (D25N, inactive) in complex with phage display optimized substrate SGIFLETS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10739.7 | 2 | UniProt (Q5RZ08) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (S) | Phage display-optimized HIV-1 protease substrate | polymer | 8 | 852.9 | 1 | Enterobacteria phage fd | ||
| 3 | D, E, F, G (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | H, I, J (A, B, S) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q5RZ08)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Asn 25 | Asp 25 | engineered mutation |
| Ile 33 | Leu 33 | engineered mutation |
| Ile 63 | Leu 63 | engineered mutation |
| Ala 67 | Cys 67 | engineered mutation |
| Ala 95 | Cys 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22332.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 141.8 | |
| All* | Total formula weight | 22474.1 |
